MolNFT v2 · #214605 · protein

hOCT1 in complex with nb5660 in inward facing partially open 2 conformation

8JTY · Solute carrier family 22 member 1: “hOCT1 in complex with nb5660 in inward facing partially open 2 conformation”. Electron microscopy at 3.26, 11 pockets (best druggability 0.85). MolNFT v2 #214605 on GenesisL1: 3D structure…

PDB: 8JTY
Type: protein
Length: 566 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.26
Source: Homo sapiens; Lama glama
Molecule: Solute carrier family 22 member 1; nanobody 56
UniProt: O15245
Pockets: 11 · best druggability 0.85

Structure

electron microscopy · resolution 3.26 · 2 distinct chains · 51% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Solute carrier family 22 member 1	protein	448	64% helix, 2% strand	O15245
B	nanobody 56	protein	118	3% helix, 43% strand	—

Pockets

11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1163	0.85	0.85	83	empty
2	318	0.71	0.84	44	empty
3	448	0.68	0.79	52	empty
4	91	0.65	0.90	16	empty
5	110	0.61	0.87	19	empty

Interfaces

1 interface between chains.

A–B · 1249 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

O15245 · AlphaFold monomer V2.0 prediction for solute carrier family 22 member 1 (O15245) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15245
Elsewhere: RCSB PDB 8JTY · PDBe 8JTY · UniProt O15245

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