UniProt O15245
Solute carrier family 22 member 1 (O15245)
Solute carrier family 22 member 1 (UniProt O15245): 13 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 102 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15245
- Protein
- Solute carrier family 22 member 1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 102 · 14 records with a druggable one
Structures
14 records of O15245 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8JTS | hOCT1 in complex with metformin in outward open conformation | electron microscopy | A | MF8 | 11 (best 0.81) |
| 8JTT | hOCT1 in complex with metformin in outward occluded conformation | electron microscopy | A | MF8 | 7 (best 0.80) |
| 8JTV | hOCT1 in complex with metformin in inward occluded conformation | electron microscopy | A | MF8 | 7 (best 0.81) |
| 8JTW | hOCT1 in complex with nb5660 in inward facing partially open 1 conformation | electron microscopy | A | — | 10 (best 0.86) |
| 8JTX | hOCT1 in complex with nb5660 in inward facing fully open conformation | electron microscopy | A | — | 12 (best 0.83) |
| 8JTY | hOCT1 in complex with nb5660 in inward facing partially open 2 conformation | electron microscopy | A | — | 11 (best 0.85) |
| 8JTZ | hOCT1 in complex with spironolactone in outward facing partially occluded conformation | electron microscopy | A | SNL | 4 (best 0.82) |
| 8JU0 | hOCT1 in complex with spironolactone in inward facing occluded conformation | electron microscopy | A | SNL | 6 (best 0.81) |
| 8SC1 | Human OCT1 (Apo) in inward-open conformation | electron microscopy | A | — | 8 (best 0.83) |
| 8SC2 | Human OCT1 bound to diltiazem in inward-open conformation | electron microscopy | A | C9F | 6 (best 0.82) |
| 8SC3 | Human OCT1 bound to fenoterol in inward-open conformation | electron microscopy | A | ZVJ | 4 (best 0.82) |
| 8SC4 | Human OCT1 bound to metformin in inward-open conformation | electron microscopy | A | MF8 | 4 (best 0.82) |
| 8SC6 | Human OCT1 bound to thiamine in inward-open conformation | electron microscopy | A | VIB | 6 (best 0.82) |
| O15245 | AlphaFold monomer V2.0 prediction for solute carrier family 22 member 1 (O15245) | predicted | A | — | 6 (best 0.80) |
Ligands
- MF8 · Metformin · in 4 records
- SNL · Spironolactone · in 2 records
- C9F · [(2~{S},3~{S})-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxidanylidene-2,3-dihydro-1,5-benzothiazepin-3-yl] ethanoate · in 1 record
- VIB · 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium · in 1 record
- ZVJ · Fenoterol · in 1 record
Experiment against prediction
- 8SC3 chain A against the predicted model O15245: TM-score 0.98, RMSD 1.09 Å
- 8JU0 chain A against the predicted model O15245: TM-score 0.98, RMSD 1.15 Å
- 8SC6 chain A against the predicted model O15245: TM-score 0.98, RMSD 1.23 Å
- 8SC2 chain A against the predicted model O15245: TM-score 0.97, RMSD 1.25 Å
- 8SC1 chain A against the predicted model O15245: TM-score 0.97, RMSD 1.32 Å
- 8SC4 chain A against the predicted model O15245: TM-score 0.97, RMSD 1.31 Å
- 8JTV chain A against the predicted model O15245: TM-score 0.96, RMSD 1.51 Å
- 8JTW chain A against the predicted model O15245: TM-score 0.91, RMSD 2.63 Å
- 8JTY chain A against the predicted model O15245: TM-score 0.91, RMSD 2.59 Å
- 8JTX chain A against the predicted model O15245: TM-score 0.90, RMSD 2.78 Å
Elsewhere
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