MolNFT v2 · #214247 · protein
Cryo-EM structure of the TcsH-TMPRSS2 complex
8JHZ · Hemorrhagic toxin: “Cryo-EM structure of the TcsH-TMPRSS2 complex”. Electron microscopy at 3.2, 1 ligand (ZN), 20 pockets (best druggability 0.84). MolNFT v2 #214247 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8JHZ
- Type
- protein
- Length
- 2,956 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.2
- Source
- Homo sapiens; Paeniclostridium sordellii
- Molecule
- Hemorrhagic toxin; Transmembrane protease serine 2
- EC
- 3.4.21.122
- UniProt
- M9ZTT7, O15393
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · resolution 3.2 · 2 distinct chains · 24% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemorrhagic toxin | protein | 2615 | 25% helix, 32% strand | M9ZTT7 |
| B | Transmembrane protease serine 2 (EC 3.4.21.122) | protein | 341 | 13% helix, 30% strand | O15393 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 544 | 0.84 | 0.89 | 55 | empty |
| 2 | 879 | 0.83 | 0.85 | 94 | empty |
| 3 | 851 | 0.78 | 0.81 | 72 | empty |
| 4 | 858 | 0.77 | 0.80 | 68 | empty |
| 5 | 752 | 0.76 | 0.81 | 63 | empty |
Interfaces
1 interface between chains.
- A–B · 1201 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 1 modified (disulfide, phosphorylation).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M9ZTT7
- Every structure of UniProt O15393
- Elsewhere: RCSB PDB 8JHZ · PDBe 8JHZ · UniProt M9ZTT7 · UniProt O15393
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