UniProt O15393
Transmembrane protease serine 2 (O15393)
Transmembrane protease serine 2 (UniProt O15393), EC 3.4.21.122: 13 experimental structures on GenesisL1, 9 ligands bound, 50 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O15393
- Protein
- Transmembrane protease serine 2
- EC
- 3.4.21.122
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 50 · 7 records with a druggable one
Structures
13 records of O15393 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MEQ | Crystal structure of human TMPRSS2 in complex with nafamostat | x-ray diffraction | A | NAG, GBS, UNX | — |
| 7Y0E | Crystal structure of TMPRSS2 in complex with Camostat | x-ray diffraction | A, C, B, D | NAG, CA, GBS | 8 (best 0.50) |
| 7Y0F | Crystal structure of TMPRSS2 in complex with UK-371804 | x-ray diffraction | A, C, B, D | NAG, CA, I9V | 8 (best 0.60) |
| 8JHZ | Cryo-EM structure of the TcsH-TMPRSS2 complex | electron microscopy | B | — | 3 (best 0.77) |
| 8S0N | Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07 | x-ray diffraction | A, C | — | 11 (best 0.74) |
| 8V1F | TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol | x-ray diffraction | A, B, C, D | NAG, FUC, TAM, UNX, 7R8 | 10 (best 0.60) |
| 8VGT | Structure of the HKU1 RBD bound to the human TMPRSS2 receptor | electron microscopy | B | NAG | 2 (best 0.55) |
| 8Y1E | 3up-TM conformation of HKU1-B S protein after incubation of the receptor | electron microscopy | D, E, F | — | 4 (best 0.76) |
| 8Y87 | Structure of HCoV-HKU1C spike in the functionally anchored-1up conformation with 1TMPRSS2 | electron microscopy | T | — | — |
| 8Y88 | Structure of HCoV-HKU1C spike in the functionally anchored-2up conformation with 2TMPRSS2 | electron microscopy | T, I | — | — |
| 8Y8A | Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 3TMPRSS2 | electron microscopy | T, H, G | — | — |
| 9E83 | TMPRSS2 crystal structure following acylation by UCSF_157 | x-ray diffraction | B, A | VU4, UNX | 4 (best 0.42) |
| O15393 | AlphaFold monomer V2.0 prediction for transmembrane protease serine 2 (O15393) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- UNX · Unknown atom or ion · in 3 records
- CA · Calcium ion · in 2 records
- GBS · 4-guanidinobenzoic acid · in 2 records
- 7R8 · 6-oxidanylnaphthalene-2-carboximidamide · in 1 record
- FUC · alpha-L-fucopyranose · in 1 record
- I9V · 2-[(1-carbamimidamido-4-chloranyl-isoquinolin-7-yl)sulfonylamino]-2-methyl-propanoic acid · in 1 record
- TAM · Tris(hydroxyethyl)aminomethane · in 1 record
- VU4 · 4-(2-aminoethyl)benzoic acid · in 1 record
Elsewhere
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