MolNFT v2 · #211876 · protein

Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751)

8HE3 · Importin subunit alpha-1: “Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751)”. X-ray diffraction at 1.9, 1 ligand (SO4), 1 pocket (best druggability 0.47). MolNFT v2 #211876 on…

PDB: 8HE3
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.9
Source: Homo sapiens; Mus musculus
Molecule: Importin subunit alpha-1; Hypoxia-inducible factor 1-alpha
UniProt: P52293
Ligands: SO4
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · resolution 1.9 · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	422	74% helix, 0% strand	P52293
B	Hypoxia-inducible factor 1-alpha	protein	8	0% helix, 0% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.47	0.82	13	empty

Interfaces

1 interface between chains.

A–B · 676 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 8HE3 · PDBe 8HE3 · UniProt P52293

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