MolNFT v2 · #211600 · protein
Crystal Structure of GTP-bound Irgb6_T95D mutant
8H4M · T-cell-specific guanine nucleotide triphosphate-binding…: “Crystal Structure of GTP-bound Irgb6_T95D mutant”. X-ray diffraction at 1.68, 1 ligand (GTP), 5 pockets (best druggability 0.62). MolNFT v2 #211600 on GenesisL1: 3D…
- PDB
- 8H4M
- Type
- protein
- Length
- 406 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.68
- Source
- Mus musculus
- Molecule
- T-cell-specific guanine nucleotide triphosphate-binding protein 2
- EC
- 3.6.5.-
- UniProt
- Q3T9E4
- Ligands
- GTP
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · resolution 1.68 · 1 distinct chain · 55% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell-specific guanine nucleotide triphosphate-binding protein 2 (EC 3.6.5.-) | protein | 406 | 55% helix, 9% strand | Q3T9E4 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.62 | 0.87 | 28 | empty |
| 2 | 202 | 0.52 | 0.77 | 29 | empty |
| 3 | 53 | 0.48 | 0.85 | 13 | empty |
| 4 | 99 | 0.40 | 0.76 | 19 | empty |
| 5 | 59 | 0.30 | 0.75 | 11 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3T9E4
- Elsewhere: RCSB PDB 8H4M · PDBe 8H4M · UniProt Q3T9E4
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