MolNFT v2 · #208350 · protein
Cryo-EM structure of the full-length human NF1 dimer
8EDN · Isoform I of Neurofibromin: “Cryo-EM structure of the full-length human NF1 dimer”. Electron microscopy at 3.8, 11 pockets (best druggability 0.82). MolNFT v2 #208350 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8EDN
- Type
- protein
- Length
- 579 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.8
- Source
- Homo sapiens
- Molecule
- Isoform I of Neurofibromin
- UniProt
- P21359
- Pockets
- 11 · best druggability 0.82
Structure
electron microscopy · resolution 3.8 · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform I of Neurofibromin | protein | 579 | 72% helix, 0% strand | P21359 |
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 705 | 0.82 | 0.86 | 93 | empty |
| 2 | 287 | 0.77 | 0.88 | 56 | empty |
| 3 | 345 | 0.70 | 0.83 | 50 | empty |
| 4 | 143 | 0.67 | 0.88 | 27 | empty |
| 5 | 194 | 0.67 | 0.85 | 31 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21359
- Elsewhere: RCSB PDB 8EDN · PDBe 8EDN · UniProt P21359
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