MolNFT v2 · #207081 · protein
CCHFV GP38 Hoti/Kosovo
8DC5 · Envelopment polyprotein: “CCHFV GP38 Hoti/Kosovo”. X-ray diffraction at 3.21, 2 ligands (NAG, IOD), 5 pockets (best druggability 0.69). MolNFT v2 #207081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8DC5
- Type
- protein
- Length
- 436 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.21
- Source
- Crimean-Congo hemorrhagic fever orthonairovirus
- Molecule
- Envelopment polyprotein
- UniProt
- A0A7T6Y557
- Ligands
- NAG, IOD
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · resolution 3.21 · 2 distinct chains · 17% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Envelopment polyprotein | protein | 217 | 18% helix, 29% strand | A0A7T6Y557 |
| B | Envelopment polyprotein | protein | 219 | 16% helix, 30% strand | A0A7T6Y557 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
- IOD · Iodide ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 835 | 0.69 | 0.75 | 74 | IOD |
| 2 | 52 | 0.36 | 0.79 | 14 | empty |
| 3 | 62 | 0.33 | 0.77 | 22 | empty |
| 4 | 56 | 0.33 | 0.77 | 13 | empty |
| 5 | 50 | 0.29 | 0.75 | 9 | empty |
Interfaces
1 interface between chains.
- A–B · 477 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 4 glycan (disulfide, N-glycosylation).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A7T6Y557
- Elsewhere: RCSB PDB 8DC5 · PDBe 8DC5 · UniProt A0A7T6Y557
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.