MolNFT v2 · #192708 · protein
Structure of human SHP2 in complex with compound 27
7R7I: “Structure of human SHP2 in complex with compound 27”. X-ray diffraction at 2.85, 1 ligand (3CW). MolNFT v2 #192708 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7R7I
- Type
- protein
- Length
- 977 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.85
- Source
- Homo sapiens
- UniProt
- Q06124
- Ligands
- 3CW
Structure
x-ray diffraction · resolution 2.85 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 489 | — | Q06124 |
| B | — | protein | 488 | — | Q06124 |
Ligands and binding sites
- 3CW · [3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7R7I · Structure of human SHP2 in complex with compound 27 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 7R7I · PDBe 7R7I · UniProt Q06124
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