MolNFT v2 · #190172 · protein

Cryo-EM structure of human TTYH2 in GDN

7P54 · Protein tweety homolog 2: “Cryo-EM structure of human TTYH2 in GDN”. Electron microscopy at 3.3, 1 ligand (NAG), 6 pockets (best druggability 0.78). MolNFT v2 #190172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7P54
Type: protein
Length: 794 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.3
Source: Homo sapiens
Molecule: Protein tweety homolog 2
UniProt: Q9BSA4
Ligands: NAG
Pockets: 6 · best druggability 0.78

Structure

electron microscopy · resolution 3.3 · 1 distinct chain · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein tweety homolog 2	protein	397	83% helix, 0% strand	Q9BSA4

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 12 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	762	0.78	0.81	49	empty
2	860	0.78	0.81	101	empty
3	714	0.77	0.81	47	empty
4	459	0.76	0.84	69	empty
5	88	0.36	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 1329 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 glycan, 4 disulfide (N-glycosylation, disulfide).

Compared structures

7P54 · Cryo-EM structure of human TTYH2 in gdn · the same entry in another collection · chain A against A, TM-score 1.00
Q9BSA4 · AlphaFold monomer V2.0 prediction for protein tweety homolog 2 (Q9BSA4) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BSA4
Elsewhere: RCSB PDB 7P54 · PDBe 7P54 · UniProt Q9BSA4

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