MolNFT v1 · #481989 · protein

AlphaFold monomer V2.0 prediction for protein tweety homolog 2 (Q9BSA4)

Q9BSA4: “AlphaFold monomer V2.0 prediction for protein tweety homolog 2 (Q9BSA4)”. 4 pockets (best druggability 0.79). MolNFT v1 #481989 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9BSA4
Type: protein
Length: 534 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xC746AF6f646b588a47acE344208619CfEF12dD4b
Molecule: Protein tweety homolog 2
UniProt: Q9BSA4
Pockets: 4 · best druggability 0.79

Structure

1 distinct chain · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein tweety homolog 2	protein	534	68% helix, 1% strand	Q9BSA4

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	705	0.79	0.83	53	empty
2	300	0.56	0.76	23	empty
3	142	0.44	0.75	21	empty
4	72	0.28	0.72	15	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

7P54 · Cryo-EM structure of human TTYH2 in gdn · an experimental structure of the same protein · chain A against A, TM-score 0.74
7P54 · Cryo-EM structure of human TTYH2 in GDN · an experimental structure of the same protein · chain A against A, TM-score 0.74
7P5M · Cryo-EM structure of human TTYH2 in lipid nanodiscs · an experimental structure of the same protein · chain A against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BSA4
Elsewhere: UniProt Q9BSA4 · AlphaFold DB Q9BSA4

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