MolNFT v2 · #188821 · protein

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300)

7O20: “X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300)”. X-ray diffraction at 1.8, 5 ligands (UYT, NAG, CA). MolNFT v2 #188821 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7O20
Type: protein
Length: 466 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Homo sapiens
UniProt: P09958
Ligands: UYT, NAG, CA, NA, CL

Structure

x-ray diffraction · resolution 1.8 · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	466	—	P09958

Ligands and binding sites

UYT · [azanyl-[(2E)-2-(1-phenylethylidene) hydrazinyl]methylidene]azanium · ligand · 3 copies · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
CA · Calcium ion · metal · 3 copies · chains A
NA · Sodium ion · metal · 2 copies · chains A
CL · Chloride ion · ion · chains A
DMS · Dimethyl sulfoxide · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7O20 · X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (MI300) · the same entry in another collection · chain A against A, TM-score 1.00
P09958 · AlphaFold monomer V2.0 prediction for furin (P09958) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09958
Elsewhere: RCSB PDB 7O20 · PDBe 7O20 · UniProt P09958

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.