MolNFT v2 · #187198 · protein
Structure of HDAC2 in complex with an inhibitor (compound 14)
7MOX: “Structure of HDAC2 in complex with an inhibitor (compound 14)”. X-ray diffraction at 1.69, 4 ligands (ZLS, CA, ZN). MolNFT v2 #187198 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MOX
- Type
- protein
- Length
- 1,102 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.69
- Source
- Homo sapiens
- UniProt
- Q92769
- Ligands
- ZLS, CA, ZN, SO4
Structure
x-ray diffraction · resolution 1.69 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 368 | — | Q92769 |
| B | — | protein | 366 | — | Q92769 |
| C | — | protein | 368 | — | Q92769 |
Ligands and binding sites
- ZLS · (1S)-N-[(1S)-7,7-dihydroxy-1-{4-[(1R,4S)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl]-1H-imidazol-2-yl}nonyl]-6-methyl-6-azaspiro[2.5]octane-1-carboxamide · ligand · 3 copies · chains A, B, C
- CA · Calcium ion · metal · 6 copies · chains A, B, C
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
- SO4 · Sulfate ion · ion · 10 copies · chains A, B, C
- PEG · Di(hydroxyethyl)ether · additive · 7 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92769
- Elsewhere: RCSB PDB 7MOX · PDBe 7MOX · UniProt Q92769
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