Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15

Structure

x-ray diffraction · resolution 2.5 · 3 distinct chains.

Ligands and binding sites

• NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · 4 copies · chains A, B, C, D
• YOJ · 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl) methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid · ligand · 4 copies · chains A, B, C, D
• SO4 · Sulfate ion · ion · 10 copies · chains A, C, B, D
• EDO · 1,2-ethanediol · additive · 75 copies · chains A, B, C, D
• GOL · Glycerol · additive · 6 copies · chains A, B, C, D
• PEG · Di(hydroxyethyl)ether · additive · 6 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7M2N · Crystal structure of human lactate dehydrogenase a with inhibitor compound 15 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00338
• Elsewhere: RCSB PDB 7M2N · PDBe 7M2N · UniProt P00338