MolNFT v2 · #185970 · protein

Structure of CD4 mimetic M48U1 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab

7LOK: “Structure of CD4 mimetic M48U1 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab”. Electron microscopy at 3.9, 3 ligands (NAG, MAN, BMA). MolNFT v2 #185970 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LOK
Type: protein
Length: 2,005 residues
Chains: 13
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.9
Source: Homo sapiens; Human immunodeficiency virus 1; SYNTHETIC CONSTRUCT
UniProt: Q2N0S6
Ligands: NAG, MAN, BMA

Structure

electron microscopy · resolution 3.9 · 10 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	—	protein	358	—	Q2N0S6
D	—	protein	126	—	Q2N0S6
A	—	protein	363	—	Q2N0S6
B	—	protein	123	—	Q2N0S6
J	—	protein	106	—	—
K, M	—	protein	129	—	—
L	—	protein	109	—	—
G, H, I	—	protein	27	—	—
F	—	protein	128	—	Q2N0S6
E	—	protein	353	—	Q2N0S6

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 14 copies · chains C, A, E
MAN · alpha-D-mannopyranose · sugar · 6 copies · chains C, A, E
BMA · beta-D-mannopyranose · sugar · 3 copies · chains A, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7LOK · Structure of CD4 mimetic M48U1 in complex with BG505 SOSIP.664 HIV-1 env trimer and 17B… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2N0S6
Elsewhere: RCSB PDB 7LOK · PDBe 7LOK · UniProt Q2N0S6

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