UniProt Q2N0S6
Envelope glycoprotein gp120 (Q2N0S6)
Envelope glycoprotein gp120 (UniProt Q2N0S6): 202 experimental structures on GenesisL1, 15 ligands bound, 1,568 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q2N0S6
- Protein
- Envelope glycoprotein gp120
- Experimental structures
- 202
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 1,568 · 95 records with a druggable one
Structures
202 records of Q2N0S6 in the MolNFT archive: 202 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J5M | Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs | electron microscopy | A, E, I | — | — |
| 3J5M | Cryo-EM structure of the BG505 SOSIP.664 HIV-1 env trimer with 3 PGV04 fabs | electron microscopy | A, E, I | — | — |
| 4NCO | Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly… | x-ray diffraction | A, E, I | — | — |
| 4NCO | Crystal structure of the BG505 sosip GP140 HIV-1 env trimer in complex with the broadly… | x-ray diffraction | A, E, I | — | — |
| 4ZMJ | Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer | x-ray diffraction | G, B | — | — |
| 4ZMJ | Crystal structure of ligand-free BG505 SOSIP.664 HIV-1 env trimer | x-ray diffraction | G, B | — | — |
| 5ACO | Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer | electron microscopy | A, B, C, D, E, F | — | — |
| 5C7K | Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies… | x-ray diffraction | C, D | — | — |
| 5C7K | Crystal structure BG505 sosip GP140 HIV-1 env trimer bound to broadly neutralizing antibodies… | x-ray diffraction | C, D | — | — |
| 5CEZ | Crystal structure of the BG505 sosip GP140 HIV-1 env trimer in complex with an early putative… | x-ray diffraction | G, B | — | — |
| 5CJX | Crystal structure of 8ANC195 Fab in complex with BG505 SOSIP.664 HIV-1 env trimer | x-ray diffraction | B, G, J, K, X, Y | — | — |
| 5D9Q | Crystal structure of the BG505 sosip GP140 HIV-1 env trimer in complex with the broadly… | x-ray diffraction | G, A, J | — | — |
| 5FYL | Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion… | x-ray diffraction | B, G | NAG, MAN, BMA | — |
| 5FYL | Crystal structure at 3.7 a resolution of fully glycosylated HIV-1 clade a BG505 SOSIP.664 prefusion… | x-ray diffraction | B, G | — | — |
| 5I8H | Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting… | x-ray diffraction | A, B, C, D | NAG, MAN | — |
| 5I8H | Crystal structure of HIV-1 BG505 SOSIP.664 prefusion env trimer in complex with V3 loop-targeting… | x-ray diffraction | A, B, C, D | — | — |
| 5T3S | HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022 | x-ray diffraction | G, B | NAG, BMA, MAN | 14 (best 0.63) |
| 5T3S | HIV GP140 trimer MD39-10MUTA in complex with fabs PGT124 and 35022 | x-ray diffraction | G, B | NAG, MAN | — |
| 5T3X | 3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env… | x-ray diffraction | B, G | NAG, FUC, MAN | 8 (best 0.78) |
| 5T3X | 3.9 ångström crystal structure of a fully and natively glycosylated BG505 SOSIP.664 HIV-1 env… | x-ray diffraction | B, G | NAG, FUC, MAN | — |
| 5T3Z | 3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env… | x-ray diffraction | B, G | NAG, FUC, MAN | 12 (best 0.78) |
| 5T3Z | 3.5 ångström crystal structure of a fully and natively glycosylated BG505 SOSIP.664 HIV-1 env… | x-ray diffraction | B, G | NAG, FUC, MAN | — |
| 5THR | Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex | electron microscopy | A, B, C, D, E, F | NAG | 20 (best 0.82) |
| 5THR | Cryo-EM structure of a BG505 env-SCD4-17B-8ANC195 complex | electron microscopy | A, B, C, D, E, F | NAG | — |
| 5U1F | Initial contact of HIV-1 Env with CD4: Cryo-EM structure of BG505 DS-SOSIP trimer in complex with… | electron microscopy | C, D, A, B, E, F | — | — |
| 5U1F | Initial contact of HIV-1 env with CD4: cryo-EM structure of BG505 ds- sosip trimer in complex with… | electron microscopy | C, D, A, B, E, F | — | — |
| 5UTF | Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations… | x-ray diffraction | G, B | NAG, MAN | 11 (best 0.71) |
| 5UTF | Crystal structure of a stabilized ds-SOSIP.6MUT BG505 GP140 HIV-1 env trimer, containing mutations… | x-ray diffraction | G, B | NAG, MAN | — |
| 5UTY | Crystal Structure of a Stabilized DS-SOSIP.mut4 BG505 gp140 HIV-1 Env Trimer, Containing Mutations… | x-ray diffraction | B, G | NAG, MAN | 9 (best 0.68) |
| 5UTY | Crystal structure of a stabilized ds-SOSIP.MUT4 BG505 GP140 HIV-1 env trimer, containing mutations… | x-ray diffraction | B, G | NAG, MAN | — |
| 5V7J | Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env… | x-ray diffraction | G, B | NAG, MAN | 10 (best 0.79) |
| 5V7J | Crystal structure at 3.7 a resolution of glycosylated HIV-1 clade a BG505 SOSIP.664 prefusion env… | x-ray diffraction | G, B | NAG, MAN | — |
| 5V8L | BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 | electron microscopy | A, B, C, D, E, F | NAG, BMA, MAN | 20 (best 0.84) |
| 5V8L | BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 | electron microscopy | A, B, C, D, E, F | NAG, BMA, MAN | — |
| 5V8M | BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117 | electron microscopy | A, B, F, I, G, J | NAG, BMA, MAN | 20 (best 0.82) |
| 5V8M | BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117 | electron microscopy | A, B, F, I, G, J | NAG, BMA | — |
| 5VIY | BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 | electron microscopy | A, B, C, D, E, F | NAG, MAN, FUC | 18 (best 0.81) |
| 5VIY | BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 | electron microscopy | A, B, C, D, E, F | NAG, MAN | — |
| 5VJ6 | BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195 | electron microscopy | A, B, C, D, E, F | — | 15 (best 0.81) |
| 5VJ6 | BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195 | electron microscopy | A, B, C, D, E, F | — | — |
| 5W6D | Crystal structure of BG505-SOSIP.v4.1-GT1-N137A in complex with Fabs 35022 and 9H/109L | x-ray diffraction | B | NAG | — |
| 5W6D | Crystal structure of BG505-SOSIP.V4.1-GT1-N137A in complex with fabs 35022 and 9H/109L | x-ray diffraction | B | NAG | — |
| 5WDU | HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and… | x-ray diffraction | G, F, Q | NAG, MAN | 17 (best 0.80) |
| 5WDU | HIV-1 env BG505 SOSIP.664 H72C-H564C trimer in complex with bnabs PGT122 Fab, 35O22 Fab and… | x-ray diffraction | G, F, Q | NAG, MAN | — |
| 6B0N | Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A… | x-ray diffraction | G | NAG, MAN | 15 (best 0.76) |
| 6B0N | Crystal structure of the cleavage-independent prefusion HIV env glycoprotein trimer of the clade a… | x-ray diffraction | G | NAG, MAN | — |
| 6CH7 | XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex… | x-ray diffraction | G | NAG, FUC, MAN | 8 (best 0.76) |
| 6CH7 | Xfel crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV- 1 envelope trimer in complex… | x-ray diffraction | G | NAG, FUC, MAN | — |
| 6CH8 | Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with… | x-ray diffraction | G | NAG, BMA, MAN | 5 (best 0.77) |
| 6CH8 | Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 envelope trimer in complex with… | x-ray diffraction | G | NAG, BMA, MAN | — |
| 6CHB | Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with… | x-ray diffraction | G, F, H | — | 17 (best 0.84) |
| 6CHB | Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 envelope trimer in complex with… | x-ray diffraction | G, F, H | — | — |
| 6CUE | Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1… | electron microscopy | c, 2, C | NAG | 19 (best 0.82) |
| 6CUF | Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1… | electron microscopy | C, 2, d | NAG, MAN | 20 (best 0.84) |
| 6DE7 | Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env… | x-ray diffraction | G | NAG, MAN, SO4 | 12 (best 0.71) |
| 6DE7 | Crystal structure at 4.3 a resolution of glycosylated HIV-1 clade a BG505 SOSIP.664 prefusion env… | x-ray diffraction | G | NAG, MAN, SO4 | — |
| 6DFG | BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding | electron microscopy | A, C, D | NAG, MAN | 20 (best 0.78) |
| 6DFG | BG505 MD39 sosip trimer in complex with mature BG18 fragment antigen binding | electron microscopy | A, C, D | NAG, MAN | — |
| 6DFH | BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding | electron microscopy | A, C, D | NAG, MAN | 19 (best 0.85) |
| 6DFH | BG505 MD64 N332-GT2 sosip trimer in complex with germline-reverted BG18 fragment antigen binding | electron microscopy | A, C, D | NAG, MAN | — |
142 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 178 records
- MAN · alpha-D-mannopyranose · in 120 records
- BMA · beta-D-mannopyranose · in 30 records
- FUC · alpha-L-fucopyranose · in 17 records
- 5VG · ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide · in 2 records
- 83G · 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione · in 2 records
- JYJ · {4-[1-(3-chlorophenyl)cyclopropane-1-carbonyl]piperazin-1-yl}(thiophen-3-yl)methanone · in 2 records
- JYS · 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-(4-bromo-7-fluoro-1H-indol-3-yl)ethane-1,2-dione · in 2 records
- JYV · (2R)-{1-[{7-[2-({[3-(dimethylamino)propyl](methyl) amino}methyl)-1,3-thiazol-4-yl]-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl}(oxo)acetyl]piperidin-4-yl}(phenyl)acetonitrile · in 2 records
- JYY · 4-{3-[{4-[(R)-cyano(phenyl)methyl]piperidin-1-yl}(oxo) acetyl]-4-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl}-N-(2-hydroxyethyl)-1,3-thiazole-2-carboxamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- 83J · 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione · in 1 record
- MPT · Beta-mercaptopropionic acid · in 1 record
- NH2 · Amino group · in 1 record
- PO4 · Phosphate ion · in 1 record
Elsewhere
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