MolNFT v2 · #183108 · protein
PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29634868
7HLP · E3 ubiquitin-protein ligase TRIM21: “PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29634868”. X-ray diffraction at 1.19, 2 ligands (A1BFB, SO4), 1 pocket (best druggability 0.51). MolNFT v2 #183108…
- PDB
- 7HLP
- Type
- protein
- Length
- 185 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.19
- Source
- Mus musculus
- Molecule
- E3 ubiquitin-protein ligase TRIM21
- EC
- 2.3.2.27
- UniProt
- Q62191
- Ligands
- A1BFB, SO4
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · resolution 1.19 · 1 distinct chain · 6% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) | protein | 185 | 6% helix, 37% strand | Q62191 |
Ligands and binding sites
- A1BFB · 2-oxo-4-propyl-2H-1-benzopyran-7-yl acetate · ligand · 2 copies · chains B
- SO4 · Sulfate ion · ion · chains B
- EDO · 1,2-ethanediol · additive · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.51 | 0.78 | 25 | A1BFB |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- Q62191 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM21 (Q62191) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62191
- Elsewhere: RCSB PDB 7HLP · PDBe 7HLP · UniProt Q62191
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