MolNFT v2 · #180058 · protein
GDP-bound KRAS G12D in complex with TH-Z816
7EW9: “GDP-bound KRAS G12D in complex with TH-Z816”. X-ray diffraction at 2.13, 3 ligands (GDP, 05C, MG). MolNFT v2 #180058 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EW9
- Type
- protein
- Length
- 501 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.13
- Source
- Homo sapiens
- UniProt
- P01116
- Ligands
- GDP, 05C, MG
Structure
x-ray diffraction · resolution 2.13 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 168 | — | P01116 |
| B | — | protein | 169 | — | P01116 |
| C | — | protein | 164 | — | P01116 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 3 copies · chains A, B, C
- 05C · 7-(8-methylnaphthalen-1-yl)-4-[(2~{R})-2-methylpiperazin-1-yl]-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EW9 · GDP-bound KRAS G12D in complex with th-Z816 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01116
- Elsewhere: RCSB PDB 7EW9 · PDBe 7EW9 · UniProt P01116
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