MolNFT v2 · #179789 · protein
Mechanism of enolase: the crystal structure of enolase-MG2+-PHOSPHOGLYCERATE(SLASH) phosphoenolpyruvate complex at 2.2-ångströms resolution
7ENL: “Mechanism of enolase: the crystal structure of enolase-MG2+-PHOSPHOGLYCERATE(SLASH) phosphoenolpyruvate…”. X-ray diffraction at 2.2, 2 ligands (2PG, MG), 3 pockets (best druggability 0.59). MolNFT v2 #179789 on GenesisL1: 3D…
- PDB
- 7ENL
- Type
- protein
- Length
- 436 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Saccharomyces cerevisiae
- Molecule
- Enolase
- EC
- 4.2.1.11
- UniProt
- P00924
- Ligands
- 2PG, MG
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · resolution 2.2 · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enolase (EC 4.2.1.11) | protein | 436 | 43% helix, 17% strand | P00924 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.59 | 0.87 | 27 | 2PG |
| 2 | 96 | 0.54 | 0.85 | 21 | empty |
| 3 | 76 | 0.44 | 0.81 | 20 | empty |
Compared structures
- 7ENL · Mechanism of enolase: the crystal structure of enolase-MG2+- PHOSPHOGLYCERATE(SLASH)… · the same entry in another collection · chain A against A, TM-score 1.00
- P00924 · AlphaFold monomer V2.0 prediction for enolase 1 (P00924) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00924
- Elsewhere: RCSB PDB 7ENL · PDBe 7ENL · UniProt P00924
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