MolNFT v1 · #177599 · protein

Mechanism of enolase: the crystal structure of enolase-MG2+- PHOSPHOGLYCERATE(SLASH) phosphoenolpyruvate complex at 2.2-ångströms resolution

7ENL: “Mechanism of enolase: the crystal structure of enolase-MG2+- PHOSPHOGLYCERATE(SLASH) phosphoenolpyruvate…”. X-ray diffraction, 2 ligands (2PG, MG), 3 pockets (best druggability 0.59). MolNFT v1 #177599 on GenesisL1: 3D structure…

PDB: 7ENL
Type: protein
Length: 436 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enolase
EC: 4.2.1.11
UniProt: P00924
Ligands: 2PG, MG
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Enolase (EC 4.2.1.11)	protein	436	43% helix, 17% strand	P00924

Ligands and binding sites

2PG · 2-phosphoglyceric acid · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.59	0.87	27	2PG
2	96	0.54	0.85	21	empty
3	76	0.44	0.81	20	empty

Compared structures

7ENL · Mechanism of enolase: the crystal structure of enolase-MG2+-PHOSPHOGLYCERATE(SLASH)… · the same entry in another collection · chain A against A, TM-score 1.00
P00924 · AlphaFold monomer V2.0 prediction for enolase 1 (P00924) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00924
Elsewhere: RCSB PDB 7ENL · PDBe 7ENL · UniProt P00924

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