MolNFT v2 · #174421 · protein
Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 6.0
7A2Z · Tyrosine-protein kinase Fyn: “Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 6.0”. X-ray diffraction at 1.14. MolNFT v2 #174421 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7A2Z
- Type
- protein
- Length
- 71 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.14
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- Tyrosine-protein kinase Fyn; VSL12
- EC
- 2.7.10.2
- UniProt
- P06241
Structure
x-ray diffraction · resolution 1.14 · 2 distinct chains · 8% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase Fyn (EC 2.7.10.2) | protein | 59 | 5% helix, 44% strand | P06241 |
| B | VSL12 | protein | 12 | 25% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 563 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7A2Z · Crystal structure of the fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- P06241 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fyn (P06241) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06241
- Elsewhere: RCSB PDB 7A2Z · PDBe 7A2Z · UniProt P06241
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