MolNFT v2 · #174252 · protein + DNA
Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2
6ZY6: “Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2”. Electron microscopy at 4.1, 1 ligand (EVP). MolNFT v2 #174252 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZY6
- Type
- protein + DNA
- Length
- 1,580 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.1
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- UniProt
- P11388
- Ligands
- EVP
Structure
electron microscopy · resolution 4.1 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 760 | — | P11388 |
| D, F | — | dna | 17 | — | — |
| E, C | — | dna | 13 | — | — |
Ligands and binding sites
- EVP · (5s,5ar,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5A,6,8,8A,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside · ligand · 2 copies · chains B, D, E, F, A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6ZY6 · Cryo-EM structure of the human topoisomerase II alpha DNA- BINDING/CLEAVAGE domain in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11388
- Elsewhere: RCSB PDB 6ZY6 · PDBe 6ZY6 · UniProt P11388
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