UniProt P11388
DNA topoisomerase 2-alpha (P11388)
DNA topoisomerase 2-alpha (UniProt P11388), EC 5.6.2.2, 5.99.1.3: 17 experimental structures on GenesisL1, 3 ligands bound, 38 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P11388
- Protein
- DNA topoisomerase 2-alpha
- EC
- 5.6.2.2, 5.99.1.3
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 38 · 2 records with a druggable one
Structures
17 records of P11388 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZXM | Human Topo IIa ATPase/AMP-PNP | x-ray diffraction | A, B | — | — |
| 1ZXM | Human topo iia ATPASE/AMP-pnp | x-ray diffraction | A, B | — | — |
| 1ZXN | Human DNA topoisomerase IIa ATPase/ADP | x-ray diffraction | A, B, C, D | — | — |
| 1ZXN | Human DNA topoisomerase iia ATPASE/ADP | x-ray diffraction | A, B, C, D | — | — |
| 4FM9 | Human topoisomerase II alpha bound to DNA | x-ray diffraction | A | — | — |
| 4FM9 | Human topoisomerase II alpha bound to DNA | x-ray diffraction | A | — | — |
| 4R1F | Re-refined Human DNA topoisomerase IIa (ATPase and transducer domains) in complex with ADP and SO4 | x-ray diffraction | A, B, C, D | — | — |
| 4R1F | Re-refined human DNA topoisomerase iia (ATPase and transducer domains) in complex with ADP and SO4 | x-ray diffraction | A, B, C, D | — | — |
| 5GWK | Human topoisomerase IIalpha in complex with DNA and etoposide | x-ray diffraction | A, B | MG, EVP | 18 (best 0.83) |
| 5GWK | Human topoisomerase iialpha in complex with DNA and etoposide | x-ray diffraction | A, B | — | — |
| 6ZY5 | Cryo-EM structure of the human topoisomerase II alpha DNA- BINDING/CLEAVAGE domain in state 1 | electron microscopy | B, A | EVP | — |
| 6ZY6 | Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 | electron microscopy | A, B | EVP | — |
| 6ZY6 | Cryo-EM structure of the human topoisomerase II alpha DNA- BINDING/CLEAVAGE domain in state 2 | electron microscopy | A, B | EVP | — |
| 6ZY7 | Cryo-EM structure of the entire Human topoisomerase II alpha in State 1 | electron microscopy | B, A | ANP, EVP | 20 (best 0.88) |
| 6ZY7 | Cryo-EM structure of the entire human topoisomerase II alpha in state 1 | electron microscopy | B, A | ANP, EVP | — |
| 6ZY8 | Cryo-EM structure of the entire human topoisomerase II alpha in state 2 | electron microscopy | A, B | ANP, EVP | — |
| P11388 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (P11388) | — | — | — |
Ligands
Elsewhere
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