MolNFT v2 · #171170 · protein
X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
6XG4: “X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim”. X-ray diffraction at 2.1, 3 ligands (NDP, TOP, CL). MolNFT v2 #171170 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6XG4
- Type
- protein
- Length
- 159 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.1
- Source
- Escherichia coli
- UniProt
- P0ABQ4
- Ligands
- NDP, TOP, CL
Structure
x-ray diffraction · resolution 2.1 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 159 | — | P0ABQ4 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- TOP · Trimethoprim · ligand · chains A
- CL · Chloride ion · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6XG4 · X-ray structure of escherichia COLI dihydrofolate reductase L28R mutant in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P0ABQ4 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P0ABQ4) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ABQ4
- Elsewhere: RCSB PDB 6XG4 · PDBe 6XG4 · UniProt P0ABQ4
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