MolNFT v2 · #170300 · protein + DNA
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC
6WPH: “Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC”. X-ray diffraction at 2.72, 3 ligands (43X, MG, SO4). MolNFT v2 #170300 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WPH
- Type
- protein + DNA
- Length
- 980 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.72
- Source
- Human immunodeficiency virus type 1 group M subtype B (isolate HXB2); SYNTHETIC…
- UniProt
- P04585
- Ligands
- 43X, MG, SO4
Structure
x-ray diffraction · resolution 2.72 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 548 | — | P04585 |
| B | — | protein | 391 | — | P04585 |
| P | — | dna | 18 | — | — |
| T | — | dna | 23 | — | — |
Ligands and binding sites
- 43X · [(2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphate · ligand · chains A, P, T
- MG · Magnesium ion · metal · 2 copies · chains A, T, B
- SO4 · Sulfate ion · ion · 2 copies · chains P, T
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6WPH · Structure of HIV-1 reverse transcriptase (rt) in complex with dsdna and (-)-ftc · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04585
- Elsewhere: RCSB PDB 6WPH · PDBe 6WPH · UniProt P04585
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