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Ligand · 43X

43X · [(2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphate

43X, [(2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphate (C8 H11 F N3 O6 P S, 327.2 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site…

Component
43X
Formula
C8 H11 F N3 O6 P S
Class
ligand
Structures
3
PDB entries
2

Binding sites

43X in 3 structures; the first of them:

  • 6WPH · Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC · 43X P901 · binds ARG72, ASP110, GLN151, ASP185, DG822, DG705
  • 5TBB · Postcatalytic ternary complex of human DNA polymerase beta with gapped DNA substrate… · 43X P101 · binds ASP190, ASP192, ARG258, TYR271, PHE272, DC10, DG6, DG7
  • 6WPH · Structure of HIV-1 reverse transcriptase (rt) in complex with dsdna and (-)-ftc · 43X P901 · binds ARG72, ASP110, GLN151, ASP185, DG822, DG705

Residues it binds most

ASP 3, DG 3, ARG 3, GLN 2, DC 1, PHE 1, TYR 1 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • SO4 · Sulfate ion
  • PPV · Pyrophosphate
  • MN · Manganese (II) ion
  • NA · Sodium ion
  • ACT · Acetate ion

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