MolNFT v2 · #166075 · protein

Crystal structure of formate dehydrogenase FDH2 enzyme from Granulicella mallensis MP5ACTX8 in the apo form.

6T8C: “Crystal structure of formate dehydrogenase FDH2 enzyme from Granulicella mallensis MP5ACTX8 in the apo form.”. X-ray diffraction at 1.97, 15 pockets (best druggability 0.78). MolNFT v2 #166075 on GenesisL1: 3D structure, binding…

PDB: 6T8C
Type: protein
Length: 1,494 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.97
Source: Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
Molecule: Formate dehydrogenase
EC: 1.17.1.9
UniProt: G8NTI5
Pockets: 15 · best druggability 0.78

Structure

x-ray diffraction · resolution 1.97 · 2 distinct chains · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Formate dehydrogenase (EC 1.17.1.9)	protein	374	36% helix, 17% strand	G8NTI5
B, D	Formate dehydrogenase (EC 1.17.1.9)	protein	373	36% helix, 17% strand	G8NTI5

Pockets

15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1193	0.78	0.80	90	empty
2	1099	0.76	0.78	79	empty
3	794	0.74	0.78	87	empty
4	476	0.71	0.81	50	empty
5	60	0.60	0.91	15	empty

Interfaces

3 interfaces between chains.

B–C · 3863 Å² buried · 43 hydrogen bonds · protein-protein
A–B · 794 Å² buried · 4 hydrogen bonds · protein-protein
B–D · 175 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6T8C · Crystal structure of formate dehydrogenase FDH2 enzyme from granulicella mallensis… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G8NTI5
Elsewhere: RCSB PDB 6T8C · PDBe 6T8C · UniProt G8NTI5

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