MolNFT v1 · #164761 · protein
Crystal structure of formate dehydrogenase FDH2 enzyme from granulicella mallensis MP5ACTX8 in the apo form.
6T8C: “Crystal structure of formate dehydrogenase FDH2 enzyme from granulicella mallensis MP5ACTX8 in the apo form.”. X-ray diffraction, 15 pockets (best druggability 0.78). MolNFT v1 #164761 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6T8C
- Type
- protein
- Length
- 1,494 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Formate dehydrogenase
- EC
- 1.17.1.9
- UniProt
- G8NTI5
- Pockets
- 15 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Formate dehydrogenase (EC 1.17.1.9) | protein | 374 | 36% helix, 17% strand | G8NTI5 |
| B, D | Formate dehydrogenase (EC 1.17.1.9) | protein | 373 | 36% helix, 17% strand | G8NTI5 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1193 | 0.78 | 0.80 | 90 | empty |
| 2 | 1099 | 0.76 | 0.78 | 79 | empty |
| 3 | 794 | 0.74 | 0.78 | 87 | empty |
| 4 | 476 | 0.71 | 0.81 | 50 | empty |
| 5 | 60 | 0.60 | 0.91 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–C · 3863 Ų buried · 43 hydrogen bonds · protein-protein
- A–B · 794 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 175 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6T8C · Crystal structure of formate dehydrogenase FDH2 enzyme from Granulicella mallensis… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8NTI5
- Elsewhere: RCSB PDB 6T8C · PDBe 6T8C · UniProt G8NTI5
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