MolNFT v2 · #161744 · protein
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(4-(2-Aminoethyl)phenyl)-4-methylquinolin-2-amine
6POU: “Structure of human endothelial nitric oxide synthase heme domain in complex with…”. X-ray diffraction at 2.194, 4 ligands (M16, HEM, ZN). MolNFT v2 #161744 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6POU
- Type
- protein
- Length
- 2,409 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.194
- Source
- Homo sapiens
- UniProt
- P29474
- Ligands
- M16, HEM, ZN, GD
Structure
x-ray diffraction · resolution 2.194 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | — | protein | 401 | — | P29474 |
| B, D, F | — | protein | 402 | — | P29474 |
Ligands and binding sites
- M16 · 7-[4-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine · ligand · 12 copies · chains A, B, C, D, E, F
- HEM · Protoporphyrin IX containing Fe · ligand · 6 copies · chains A, B, C, D, E, F
- ZN · Zinc ion · metal · 9 copies · chains A, B, C, D, E, F
- GD · Gadolinium atom · metal · 8 copies · chains A, B, C, D, F
- BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · 18 copies · chains A, F, B, C, D, E
- GOL · Glycerol · additive · 2 copies · chains C, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6POU · Structure of human endothelial nitric oxide synthase heme domain in complex with… · the same entry in another collection · chain F against F, TM-score 1.00
- P29474 · AlphaFold monomer V2.0 prediction for nitric oxide synthase, endothelial (P29474) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29474
- Elsewhere: RCSB PDB 6POU · PDBe 6POU · UniProt P29474
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.