MolNFT v2 · #161615 · protein

Trk-a in complex with ligand 1B

6PL1: “Trk-a in complex with ligand 1B”. X-ray diffraction at 2.03, 1 ligand (OOJ). MolNFT v2 #161615 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6PL1
Type: protein
Length: 290 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.03
Source: Homo sapiens
UniProt: P04629
Ligands: OOJ

Structure

x-ray diffraction · resolution 2.03 · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	290	—	P04629

Ligands and binding sites

OOJ · N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl) methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6PL1 · Trk-a in complex with ligand 1B · the same entry in another collection · chain A against A, TM-score 1.00
P04629 · AlphaFold monomer V2.0 prediction for high affinity nerve growth factor receptor (P04629) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04629
Elsewhere: RCSB PDB 6PL1 · PDBe 6PL1 · UniProt P04629

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