Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium

Structure

x-ray diffraction · resolution 2.541 · 1 distinct chain.

Ligands and binding sites

• OLA · Oleic acid · ligand · 2 copies · chains A
• 0HK · (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane · ligand · chains A
• P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol · additive · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6OL9 · Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium · the same entry in another collection · chain A against A, TM-score 1.00
• P08912 · AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M5 (P08912) · a predicted model of the same protein · chain A against A, TM-score 0.72

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P08912
• Every structure of UniProt D9IEF7
• Elsewhere: RCSB PDB 6OL9 · PDBe 6OL9 · UniProt P08912 · UniProt D9IEF7