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MolNFT v2 · #158487 · protein

Avian mitochondrial complex II with Atpenin A5 bound, sidechain in pocket

6MYT: “Avian mitochondrial complex II with Atpenin A5 bound, sidechain in pocket”. X-ray diffraction at 2.27, 11 ligands (UNL, FAD, OAA). MolNFT v2 #158487 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
6MYT
Type
protein
Length
1,092 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
2.27
Source
Gallus gallus
UniProt
F1NPJ4, Q9YHT2, D0VWW3, Q5ZIS0
Ligands
UNL, FAD, OAA, FES, SF4, F3S, AT5, HEM, UMQ, 3PE, K

Structure

x-ray diffraction · resolution 2.27 · 4 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein611—F1NPJ4
B—protein240—Q9YHT2
C—protein139—D0VWW3
D—protein102—Q5ZIS0

Ligands and binding sites

  • UNL · Unknown ligand · ligand · 59 copies · chains A, B, C, D
  • FAD · Flavin-adenine dinucleotide · ligand · chains A
  • OAA · Oxaloacetate ion · ligand · chains A
  • FES · Fe2/s2 (inorganic) cluster · ligand · chains B
  • SF4 · Iron/sulfur cluster · ligand · chains B
  • F3S · FE3-S4 cluster · ligand · chains B
  • AT5 · 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone · ligand · chains B, C, D
  • HEM · Protoporphyrin IX containing Fe · ligand · chains B, C, D
  • UMQ · Undecyl-maltoside · ligand · chains B, C
  • 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · chains C, D
  • K · Potassium ion · metal · chains A
  • PEG · Di(hydroxyethyl)ether · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6MYT · Avian mitochondrial complex II with atpenin A5 bound, sidechain in pocket · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9YHT2 · AlphaFold monomer V2.0 prediction for succinate dehydrogenase [ubiquinone] iron-sulfur… · a predicted model of the same protein · chain B against A, TM-score 1.00
  • Q5ZIS0 · AlphaFold monomer V2.0 prediction for succinate dehydrogenase [ubiquinone] cytochrome B… · a predicted model of the same protein · chain D against A, TM-score 0.99

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