MolNFT v2 · #157027 · protein
Structural basis for broad specificity in alpha-lytic protease mutants
6LPR: “Structural basis for broad specificity in alpha-lytic protease mutants”. X-ray diffraction at 2.1, 1 ligand (SO4). MolNFT v2 #157027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LPR
- Type
- protein
- Length
- 202 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.1
- Source
- Lysobacter enzymogenes; SYNTHETIC CONSTRUCT
- Molecule
- Alpha-lytic protease; Methoxysuccinyl-ala-ala-pro-norleucine boronic acid inhibitor
- EC
- 3.4.21.12
- UniProt
- P00778
- Ligands
- SO4
Structure
x-ray diffraction · resolution 2.1 · 2 distinct chains · 6% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-lytic protease (EC 3.4.21.12) | protein | 198 | 7% helix, 55% strand | P00778 |
| P | Methoxysuccinyl-ala-ala-pro-norleucine boronic acid inhibitor | protein | 4 | 0% helix, 25% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–P · 370 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 1 modified (disulfide, nonstandard).
Compared structures
- 6LPR · Structural basis for broad specificity in alpha-lytic protease mutants · the same entry in another collection · chain A against A, TM-score 1.00
- P00778 · AlphaFold monomer V2.0 prediction for alpha-lytic protease (P00778) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00778
- Elsewhere: RCSB PDB 6LPR · PDBe 6LPR · UniProt P00778
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