MolNFT v2 · #153819 · protein
Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor
6IUO: “Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor”. X-ray diffraction at 2.3, 1 ligand (AWX). MolNFT v2 #153819 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IUO
- Type
- protein
- Length
- 275 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.3
- Source
- Homo sapiens
- UniProt
- P22455
- Ligands
- AWX
Structure
x-ray diffraction · resolution 2.3 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 275 | — | P22455 |
Ligands and binding sites
- AWX · N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6IUO · Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22455
- Elsewhere: RCSB PDB 6IUO · PDBe 6IUO · UniProt P22455
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