MolNFT v2 · #152356 · protein
Crystal structure of human BRD9 bromodomain in complex with a PROTAC
6HM0: “Crystal structure of human BRD9 bromodomain in complex with a PROTAC”. X-ray diffraction at 2.4, 1 ligand (GBW). MolNFT v2 #152356 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HM0
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.4
- Source
- Homo sapiens
- UniProt
- Q9H8M2
- Ligands
- GBW
Structure
x-ray diffraction · resolution 2.4 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 112 | — | Q9H8M2 |
Ligands and binding sites
- GBW · (2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl) phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl) phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6HM0 · Crystal structure of human BRD9 bromodomain in complex with a protac · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H8M2 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 9 (Q9H8M2) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H8M2
- Elsewhere: RCSB PDB 6HM0 · PDBe 6HM0 · UniProt Q9H8M2
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