UniProt Q9H8M2
Bromodomain-containing protein 9 (Q9H8M2)
Bromodomain-containing protein 9 (UniProt Q9H8M2): 59 experimental structures and 1 predicted model on GenesisL1, 21 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H8M2
- Protein
- Bromodomain-containing protein 9
- Experimental structures
- 59
- Predicted models
- 1
- Ligands
- 21
- Pockets
- 4 · 0 records with a druggable one
Structures
60 records of Q9H8M2 in the MolNFT archive: 59 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HME | Crystal structure of human bromodomain containing 9 isoform 1 (BRD9) | x-ray diffraction | A, B | — | — |
| 3HME | Crystal structure of human bromodomain containing 9 isoform 1 (BRD9) | x-ray diffraction | A, B | — | — |
| 4UIV | BROMODOMAIN OF HUMAN BRD9 WITH N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4… | x-ray diffraction | A | — | — |
| 4UIV | Bromodomain of human BRD9 with N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4… | x-ray diffraction | A | — | — |
| 4XY8 | Crystal Structure of the bromodomain of BRD9 in complex with a 2-amine-9H-purine ligand | x-ray diffraction | A | — | — |
| 4XY8 | Crystal structure of the bromodomain of BRD9 in complex with a 2- amine-9H-purine ligand | x-ray diffraction | A | — | — |
| 4YY4 | Crystal structure of BRD9 Bromodomain bound to DMSO | x-ray diffraction | A | — | — |
| 4YY4 | Crystal structure of BRD9 bromodomain bound to dmso | x-ray diffraction | A | — | — |
| 4YY6 | Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide | x-ray diffraction | A | — | — |
| 4YY6 | Crystal structure of BRD9 bromodomain bound to a butyryllysine peptide | x-ray diffraction | A | — | — |
| 4YYD | Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide | x-ray diffraction | A | — | — |
| 4YYD | Crystal structure of BRD9 bromodomain bound to a crotonyllysine peptide | x-ray diffraction | A | — | — |
| 4YYG | Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide | x-ray diffraction | A | — | — |
| 4YYG | Crystal structure of BRD9 bromodomain bound to a butyryllysine peptide | x-ray diffraction | A | — | — |
| 4YYH | Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide | x-ray diffraction | A, B | — | — |
| 4YYH | Crystal structure of BRD9 bromodomain bound to a crotonyllysine peptide | x-ray diffraction | A, B | — | — |
| 4YYI | Crystal structure of BRD9 Bromodomain bound to an acetylated peptide | x-ray diffraction | A, B, D, E | — | — |
| 4YYI | Crystal structure of BRD9 bromodomain bound to an acetylated peptide | x-ray diffraction | A, B, D, E | — | — |
| 4YYJ | Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide | x-ray diffraction | A, B, D, E | — | — |
| 4YYJ | Crystal structure of BRD9 bromodomain bound to a butyryllysine peptide | x-ray diffraction | A, B, D, E | — | — |
| 4YYK | Crystal structure of BRD9 bromodomain bound to a crotonyllysine peptide | x-ray diffraction | A, B, D, E | — | — |
| 4Z6H | Crystal structure of BRD9 bromodomain in complex with a valerolactam quinolone ligand | x-ray diffraction | A, B | 4L2 | 3 (best 0.45) |
| 4Z6H | Crystal structure of BRD9 bromodomain in complex with a valerolactam quinolone ligand | x-ray diffraction | A, B | — | — |
| 4Z6I | Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand | x-ray diffraction | A, B | — | — |
| 4Z6I | Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand | x-ray diffraction | A, B | — | — |
| 5E9V | Crystal structure of BRD9 bromodomain in complex with an indolizine ligand | x-ray diffraction | A, B | — | — |
| 5EU1 | Crystal structure of BRD9 in complex with bi-7273 | x-ray diffraction | A, B | — | — |
| 5F1H | Crystal structure of the BRD9 bromodamian in complex with BI-9564. | x-ray diffraction | A, B | 5U6 | — |
| 5F1H | Crystal structure of the BRD9 bromodamian in complex with bi-9564. | x-ray diffraction | A, B | — | — |
| 5F1L | Crystal structure of the bromodomain of BRD9 in complex with compound 9. | x-ray diffraction | A, B | — | — |
| 5F25 | Crystal structure of the BRD9 bromodomain in complex with compound 4. | x-ray diffraction | A, B | — | — |
| 5F2P | Crystal structure of the BRD9 bromodomain in complex with compound 3. | x-ray diffraction | A, B | — | — |
| 5I40 | BRD9 in complex with CPD1 (6-methyl-1,6-dihydro-7H-PYRROLO[2,3- C]PYRIDIN-7-one) | x-ray diffraction | A | — | — |
| 5I7X | BRD9 in complex with CPD2 (N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro… | x-ray diffraction | A | — | — |
| 5I7Y | BRD9 in complex with CPD4 ((E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro… | x-ray diffraction | A | — | — |
| 5IGM | Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (bsp) | x-ray diffraction | A, B | — | — |
| 5IGN | Crystal structure of human BRD9 bromodomain in complex with LP99 chemical probe | x-ray diffraction | A, B | 6B2 | — |
| 5IGN | Crystal structure of human BRD9 bromodomain in complex with LP99 chemical probe | x-ray diffraction | A, B | — | — |
| 5JI8 | Crystal structure of the BRD9 bromodomain and hit 1 | x-ray diffraction | A | 6KT | 1 (best 0.45) |
| 5JI8 | Crystal structure of the BRD9 bromodomain and hit 1 | x-ray diffraction | A | — | — |
| 5MKY | BROMODOMAIN OF HUMAN BRD9 WITH 4-chloro-2-methyl-5-((2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)ami… | x-ray diffraction | A | I0D | — |
| 5MKY | Bromodomain of human BRD9 with 4-chloro-2-methyl-5-((2-methyl-1,2,3,4… | x-ray diffraction | A | I0D | — |
| 5TWX | Crystal structure of BRD9 bromodomain | x-ray diffraction | A, B, C, D | 7P7 | — |
| 6BQA | BRD9 bromodomain in complex with 3-(6-(but-3-en-1-yl)-7-oxo-6,7… | x-ray diffraction | A | 67C | — |
| 6HM0 | Crystal structure of human BRD9 bromodomain in complex with a PROTAC | x-ray diffraction | A, B | GBW | — |
| 6HM0 | Crystal structure of human BRD9 bromodomain in complex with a protac | x-ray diffraction | A, B | GBW | — |
| 6UZF | Crystal structure of the unliganded bromodomain of human BRD9 | x-ray diffraction | A | SO4 | — |
| 6V0S | Crystal structure of the bromodomain of human BRD9 bound to TG003 | x-ray diffraction | A, B | EAE | — |
| 6V0X | Crystal structure of the bromodomain of human BRD9 bound to sunitinib | x-ray diffraction | A | B49 | — |
| 6V14 | Crystal structure of the bromodomain of human BRD9 bound to TP472 | x-ray diffraction | A | QMG | — |
| 6V14 | Crystal structure of the bromodomain of human BRD9 bound to TP472 | x-ray diffraction | A | QMG | — |
| 6V1B | Crystal structure of the bromodomain of human BRD9 bound to I-BRD9 | x-ray diffraction | A, B | H1B | — |
| 6Y7H | Structure of the BRD9 bromodomain and compound 11 | x-ray diffraction | A, B | OFK | — |
| 6Y7I | Structure of the BRD9 bromodomain and compound 2 | x-ray diffraction | A, B | OF8 | — |
| 6Y7J | Structure of the BRD9 bromodomain and compound 15 | x-ray diffraction | A, B | OF5, CL | — |
| 6Y7K | Structure of the BRD9 bromodomain and compound 27 | x-ray diffraction | A | OEZ, NA | — |
| 6Y7L | Structure of the BRD9 bromodomain and tp-472 | x-ray diffraction | A | QMG | — |
| 6YQW | BRD9 with 4-chloro-2-methyl-methylamino-pyridazinone | x-ray diffraction | A | 82I | — |
| 8A7I | Crystal structure of BRD9 bromodomain in complex with compound ea-89 | x-ray diffraction | A, B | L8L | — |
| Q9H8M2 | AlphaFold monomer V2.0 prediction for bromodomain-containing protein 9 (Q9H8M2) | predicted | A | — | — |
Ligands
- QMG · 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide · in 3 records
- GBW · (2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl) phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl) phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 2 records
- I0D · 4-chloranyl-2-methyl-5-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-5-yl)amino]pyridazin-3-one · in 2 records
- 4L2 · 1,4-dimethyl-7-(2-oxopiperidin-1-yl)quinolin-2(1H)-one · in 1 record
- 5U6 · 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one · in 1 record
- 67C · 3-[6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl]-N,N-dimethylbenzamide · in 1 record
- 6B2 · N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide · in 1 record
- 6KT · 2-amino-1,3-benzothiazole-6-carboxamide · in 1 record
- 7P7 · N-[6-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)hexyl]-2-(4-{2-[N-(1,1-dioxo-1lambda~6~-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)acetamide · in 1 record
- 82I · 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one · in 1 record
- B49 · N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide · in 1 record
- CL · Chloride ion · in 1 record
- EAE · (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one · in 1 record
- H1B · N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide · in 1 record
- L8L · ~{N}-[1,1-bis(oxidanylidene)thian-4-yl]-7-[3-methyl-1-(piperidin-4-ylmethyl)indol-5-yl]-4-oxidanylidene-5-propyl-thieno[3,2-c]pyridine-2-carboxamide · in 1 record
- NA · Sodium ion · in 1 record
- OEZ · ~{N}-cyclobutyl-3-(6-ethanoylpyrrolo[1,2-a]pyrimidin-8-yl)-4-methoxy-benzamide · in 1 record
- OF5 · 1-[8-(2,5-dimethoxyphenyl)pyrrolo[1,2-a]pyrimidin-6-yl]ethanone · in 1 record
- OF8 · 1-(8-pyridin-2-ylpyrrolo[1,2-a]pyrimidin-6-yl)ethanone · in 1 record
- OFK · 1-(8-phenylpyrrolo[1,2-a]pyrimidin-6-yl)ethanone · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5I7Y chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.26 Å
- 4YYH chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.28 Å
- 4YYH chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.28 Å
- 5I7X chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.28 Å
- 5JI8 chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.30 Å
- 5JI8 chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.30 Å
- 4UIV chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.30 Å
- 4UIV chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.30 Å
- 5MKY chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.30 Å
- 5MKY chain A against the predicted model Q9H8M2: TM-score 0.99, RMSD 0.30 Å
Elsewhere
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