MolNFT v2 · #152042 · protein
Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab
6HCO: “Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab”. Electron microscopy at 3.58, 2 ligands (FY5, NAG). MolNFT v2 #152042 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HCO
- Type
- protein
- Length
- 1,576 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.58
- Source
- Homo sapiens; Mus musculus
- UniProt
- Q9UNQ0
- Ligands
- FY5, NAG
Structure
electron microscopy · resolution 3.58 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 563 | — | Q9UNQ0 |
| C, E | — | protein | 107 | — | — |
| D, F | — | protein | 118 | — | — |
Ligands and binding sites
- FY5 · estrone 3-sulfate · ligand · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, D, F, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6HCO · Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab · the same entry in another collection · chain F against F, TM-score 1.00
- Q9UNQ0 · AlphaFold monomer V2.0 prediction for broad substrate specificity ATP-binding cassette… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNQ0
- Elsewhere: RCSB PDB 6HCO · PDBe 6HCO · UniProt Q9UNQ0
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