MolNFT v2 · #151769 · protein
Crystal structure of human KDM4A in complex with compound 17f
6H4R: “Crystal structure of human KDM4A in complex with compound 17f”. X-ray diffraction at 2.14, 3 ligands (FQB, ZN, CL). MolNFT v2 #151769 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6H4R
- Type
- protein
- Length
- 1,355 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.14
- Source
- Homo sapiens
- UniProt
- O75164
- Ligands
- FQB, ZN, CL
Structure
x-ray diffraction · resolution 2.14 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 340 | — | O75164 |
| B | — | protein | 340 | — | O75164 |
| C | — | protein | 341 | — | O75164 |
| D | — | protein | 334 | — | O75164 |
Ligands and binding sites
- FQB · 8-[4-[2-[4-[4-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · ligand · 4 copies · chains A, B, C, D
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
- CL · Chloride ion · ion · chains C
- GOL · Glycerol · additive · 2 copies · chains A, C, B
- DMS · Dimethyl sulfoxide · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6H4R · Crystal structure of human KDM4A in complex with compound 17F · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75164
- Elsewhere: RCSB PDB 6H4R · PDBe 6H4R · UniProt O75164
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