crystal structure of the human TGT catalytic subunit QTRT1 in complex with queuine

Structure

x-ray diffraction · resolution 2.4 · 2 distinct chains.

Ligands and binding sites

• QEI · 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · 2 copies · chains A, B
• K · Potassium ion · metal · 2 copies · chains A, B
• CL · Chloride ion · ion · 5 copies · chains A, B
• BR · Bromide ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6H45 · Crystal structure of the human tgt catalytic subunit QTRT1 in complex with queuine · the same entry in another collection · chain A against A, TM-score 1.00
• Q9BXR0 · AlphaFold monomer V2.0 prediction for queuine tRNA-ribosyltransferase catalytic subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9BXR0
• Elsewhere: RCSB PDB 6H45 · PDBe 6H45 · UniProt Q9BXR0