MolNFT v2 · #151161 · protein + DNA

X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA aptamer, in the presence of sodium ions.

6GN7: “X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA…”. X-ray diffraction at 2.8, 6 ligands (NAG, BMA, MAN). MolNFT v2 #151161 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6GN7
Type: protein + DNA
Length: 318 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.8
Source: Homo sapiens; SYNTHETIC CONSTRUCT
UniProt: P00734
Ligands: NAG, BMA, MAN, GAL, SIA, NA

Structure

x-ray diffraction · resolution 2.8 · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	—	protein	33	—	P00734
H	—	protein	259	—	P00734
E	—	dna	26	—	—

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains H
BMA · beta-D-mannopyranose · sugar
MAN · alpha-D-mannopyranose · sugar
GAL · beta-D-galactopyranose · sugar
SIA · N-acetyl-alpha-neuraminic acid · sugar
NA · Sodium ion · metal · 2 copies · chains H, E
GOL · Glycerol · additive · chains H, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6GN7 · X-ray structure of the complex between human alpha thrombin and NU172, a… · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00734
Elsewhere: RCSB PDB 6GN7 · PDBe 6GN7 · UniProt P00734

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