MolNFT v2 · #145083 · protein
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
6BM7: “Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine…”. X-ray diffraction at 2.98, 2 ligands (DY7, PUT). MolNFT v2 #145083 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BM7
- Type
- protein
- Length
- 1,278 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.98
- Source
- Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
- UniProt
- Q587A7, A5HNV6
- Ligands
- DY7, PUT
Structure
x-ray diffraction · resolution 2.98 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 77 | — | Q587A7 |
| B, D | — | protein | 271 | — | Q587A7 |
| C | — | protein | 79 | — | Q587A7 |
| E | — | protein | 291 | — | A5HNV6 |
| F | — | protein | 289 | — | A5HNV6 |
Ligands and binding sites
- DY7 · 2-amino-4-[(3,5-dibromophenyl)amino]-6-methylpyrimidin-1-ium · ligand · 2 copies · chains A, B, C, D
- PUT · 1,4-diaminobutane · ligand · 2 copies · chains E, F
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B, C, D
- PGE · Triethylene glycol · additive · 2 copies · chains E
- PG4 · Tetraethylene glycol · additive · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6BM7 · Crystal structure of trypanosoma brucei ADOMETDC/PROZYME heterodimer in complex with… · the same entry in another collection · chain F against F, TM-score 1.00
- A5HNV6 · AlphaFold monomer V2.0 prediction for inactive S-adenosylmethionine decarboxylase prozyme… · a predicted model of the same protein · chain E against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q587A7
- Every structure of UniProt A5HNV6
- Elsewhere: RCSB PDB 6BM7 · PDBe 6BM7 · UniProt Q587A7 · UniProt A5HNV6
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