MolNFT v1 · #144193 · protein
Crystal structure of trypanosoma brucei ADOMETDC/PROZYME heterodimer in complex with pyrimidineamine inhibitor UTSAM568
6BM7: “Crystal structure of trypanosoma brucei ADOMETDC/PROZYME heterodimer in complex with pyrimidineamine…”. X-ray diffraction, 3 ligands (PYR, DY7, PUT). MolNFT v1 #144193 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BM7
- Type
- protein
- Length
- 1,276 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q587A7, A5HNV6
- Ligands
- PYR, DY7, PUT
Structure
x-ray diffraction · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 77 | — | Q587A7 |
| B, D | — | protein | 270 | — | Q587A7 |
| C | — | protein | 79 | — | Q587A7 |
| E | — | protein | 291 | — | A5HNV6 |
| F | — | protein | 289 | — | A5HNV6 |
Ligands and binding sites
- PYR · Pyruvic acid · ligand · 2 copies · chains A, B, C, D
- DY7 · 2-amino-4-[(3,5-dibromophenyl)amino]-6-methylpyrimidin-1-ium · ligand · 2 copies · chains A, B, C, D
- PUT · 1,4-diaminobutane · ligand · 2 copies · chains E, F
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B, C, D
- PGE · Triethylene glycol · additive · 2 copies · chains E
- PG4 · Tetraethylene glycol · additive · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6BM7 · Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with… · the same entry in another collection · chain F against F, TM-score 1.00
- A5HNV6 · AlphaFold monomer V2.0 prediction for inactive S-adenosylmethionine decarboxylase prozyme… · a predicted model of the same protein · chain E against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q587A7
- Every structure of UniProt A5HNV6
- Elsewhere: RCSB PDB 6BM7 · PDBe 6BM7 · UniProt Q587A7 · UniProt A5HNV6
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