MolNFT v2 · #144367 · protein
IDH1 R132H mutant in complex with IDH305
6B0Z: “IDH1 R132H mutant in complex with IDH305”. X-ray diffraction at 2.334, 2 ligands (C81, NDP). MolNFT v2 #144367 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6B0Z
- Type
- protein
- Length
- 1,617 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.334
- Source
- Homo sapiens
- UniProt
- O75874
- Ligands
- C81, NDP
Structure
x-ray diffraction · resolution 2.334 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 399 | — | O75874 |
| C | — | protein | 410 | — | O75874 |
| B | — | protein | 409 | — | O75874 |
| D | — | protein | 399 | — | O75874 |
Ligands and binding sites
- C81 · (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino) pyrimidin-4-yl]-1,3-oxazolidin-2-one · ligand · 6 copies · chains A, C, B, D
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, C, B, D
- FLC · Citrate anion · additive · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75874
- Elsewhere: RCSB PDB 6B0Z · PDBe 6B0Z · UniProt O75874
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