MolNFT v2 · #143641 · protein
Crystal structure of human FTO in complex with small-molecule inhibitors
6AEJ: “Crystal structure of human FTO in complex with small-molecule inhibitors”. X-ray diffraction at 2.8, 2 ligands (7YC, ZN). MolNFT v2 #143641 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6AEJ
- Type
- protein
- Length
- 421 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.8
- Source
- Homo sapiens
- UniProt
- Q9C0B1
- Ligands
- 7YC, ZN
Structure
x-ray diffraction · resolution 2.8 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 421 | — | Q9C0B1 |
Ligands and binding sites
- 7YC · (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6AEJ · Crystal structure of human fto in complex with small-molecule inhibitors · the same entry in another collection · chain A against A, TM-score 1.00
- Q9C0B1 · AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent dioxygenase fto… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0B1
- Elsewhere: RCSB PDB 6AEJ · PDBe 6AEJ · UniProt Q9C0B1
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