Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA') in complex with the indenoindole-type inhibitor 4P

Structure

x-ray diffraction · resolution 1.998 · 2 distinct chains.

Ligands and binding sites

• 9YE · 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione · ligand · 2 copies · chains A, B
• NA · Sodium ion · metal · chains A
• ACT · Acetate ion · additive · 4 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5OOI · Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA') in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
• P19784 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha' (P19784) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19784
• Elsewhere: RCSB PDB 5OOI · PDBe 5OOI · UniProt P19784