UniProt P19784
Casein kinase II subunit alpha' (P19784)
Casein kinase II subunit alpha' (UniProt P19784), EC 2.7.11.1: 40 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P19784
- Protein
- Casein kinase II subunit alpha'
- EC
- 2.7.11.1
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 31 · 6 records with a druggable one
Structures
41 records of P19784 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3E3B | Crystal structure of catalytic subunit of human protein kinase CK2alpha prime with a potent… | x-ray diffraction | X | — | — |
| 3E3B | Crystal structure of catalytic subunit of human protein kinase CK2ALPHA prime with a potent… | x-ray diffraction | X | — | — |
| 3OFM | Structure of a human CK2alpha prime, the paralog isoform of the catalytic subunit of protein kinase… | x-ray diffraction | A | — | — |
| 3OFM | Structure of a human CK2ALPHA prime, the paralog isoform of the catalytic subunit of protein kinase… | x-ray diffraction | A | — | — |
| 3U87 | Structure of a chimeric construct of human CK2alpha and human CK2alpha' in complex with a… | x-ray diffraction | A, B | — | — |
| 3U87 | Structure of a chimeric construct of human CK2ALPHA and human CK2ALPHA' in complex with a… | x-ray diffraction | A, B | — | — |
| 5M4U | Orthorhombic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2ALPHA')… | x-ray diffraction | A | 7FC, CL, SO4 | — |
| 5M56 | Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with… | x-ray diffraction | A, B | 7FC, CL | — |
| 5M56 | Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2ALPHA') with… | x-ray diffraction | A, B | 7FC, CL | — |
| 5OOI | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA') in complex with the… | x-ray diffraction | A, B | 9YE, NA | — |
| 5OOI | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA') in complex with the… | x-ray diffraction | A, B | 9YE, NA | — |
| 5Y9M | Crystal structure of CK2A2 form 3 | x-ray diffraction | X, A | NIO, SO4 | — |
| 5YF9 | Crystal structure of CK2A2 form-2 | x-ray diffraction | X, B | NIO, SO4 | — |
| 5YWM | Crystal structure of CK2A2 form-1 | x-ray diffraction | X | SO4, NIO | — |
| 6HMB | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 Gene product) IN… | x-ray diffraction | A | CL, 3NG | — |
| 6HMB | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA'; CSNK2A2 gene product) in… | x-ray diffraction | A | CL, 3NG | — |
| 6HMC | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN… | x-ray diffraction | A | FXB | — |
| 6HMC | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA'; CSNK2A2 gene product) in… | x-ray diffraction | A | FXB | — |
| 6HMD | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN… | x-ray diffraction | A | GDW, CL | — |
| 6HMD | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA'; CSNK2A2 gene product) in… | x-ray diffraction | A | GDW, CL | — |
| 6HMQ | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA'; CSNK2A2 gene product) in… | x-ray diffraction | A | CL, NA, 4B0 | — |
| 6L20 | Crystal structure of CK2A2 with hematein | x-ray diffraction | A, D, G, J | E3U, CL | — |
| 6QY8 | Human CSNK2A2 bound to ERB-041 | x-ray diffraction | A, B, C, D | 041 | 11 (best 0.81) |
| 6QY8 | Human CSNK2A2 bound to erb-041 | x-ray diffraction | A, B, C, D | 041 | — |
| 6QY9 | Human CSNK2A2 bound to a PYRROLO[2,3-D]PYRIMIDINYL inhibitor | x-ray diffraction | A | JL2, CL | — |
| 6TE2 | Crystal structure of human protein kinase CK2ALPHA' (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | N4N | — |
| 6TEW | Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | N5Q | — |
| 6TEW | Crystal structure of human protein kinase CK2ALPHA' (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | N5Q | — |
| 6TGU | Crystal structure of human protein kinase CK2ALPHA'(CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | N92 | — |
| 7A1B | Crystal structure of human protein kinase CK2ALPHA' (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | QXW, CL, NA | — |
| 7A1Z | Crystal structure of human protein kinase CK2ALPHA' (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | QWN, CL | — |
| 7A22 | Crystal structure of human protein kinase CK2ALPHA' (CSNK2A2 gene product) in complex with the… | — | — | — | |
| 7A2H | Crystal structure of human protein kinase CK2ALPHA' (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | QX2 | — |
| 7AT9 | Structure of protein kinase ck2 catalytic subunit (csnk2a2 gene product) in complex with the… | x-ray diffraction | A | 42J, CL, 4B0, NA | 2 (best 0.74) |
| 7AT9 | Structure of protein kinase CK2 catalytic subunit (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | 42J, CL, 4B0, NA | — |
| 7ATV | Structure of protein kinase CK2 catalytic subunit (CSNK2A2 gene product) in complex with the… | x-ray diffraction | A | RXE, CL | — |
| 7XYH | Crystal structure of CK2a2 complexed with AG1112 | x-ray diffraction | A, B | 8BH | 6 (best 0.79) |
| 8QBU | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA'; CSNK2A2 gene product) in… | x-ray diffraction | A | 42J, 3NG | 3 (best 0.65) |
| 8QCD | Structure of protein kinase CK2 catalytic subunit (isoform CK2ALPHA'; CSNK2A2 gene product) in… | x-ray diffraction | A | TBS | 3 (best 0.67) |
| 8QCG | Structure of the catalytic subunit of protein kinase CK2 (CK2ALPHA') in complex with the… | x-ray diffraction | A, B | ANP, MG | 6 (best 0.80) |
| P19784 | AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha' (P19784) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 15 records
- NA · Sodium ion · in 6 records
- SO4 · Sulfate ion · in 4 records
- 3NG · 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid · in 3 records
- 42J · 2-(3,4-dichlorophenyl)ethanamine · in 3 records
- 4B0 · 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol · in 3 records
- 7FC · 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid · in 3 records
- NIO · Nicotinic acid · in 3 records
- 041 · 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol · in 2 records
- 9YE · 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione · in 2 records
- FXB · 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione · in 2 records
- GDW · 5-[2-(diethylamino)ethyl]-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione · in 2 records
- N5Q · 4-[(4-naphthalen-2-yl-1,3-thiazol-2-yl)amino]-2-oxidanyl-benzoic acid · in 2 records
- 8BH · 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- E3U · (6AR)-3,4,6A,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2, 1-c]chromen-9-one · in 1 record
- JL2 · 3-[3-[2-[(3,4,5-trimethoxyphenyl)amino]pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]propanenitrile · in 1 record
- MG · Magnesium ion · in 1 record
- N4N · 3-[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]benzoic acid · in 1 record
- N92 · 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]-2-oxidanyl-benzoic acid · in 1 record
- QWN · 6-bromanyl-5-chloranyl-1~{H}-[1,2,3]triazolo[4,5-b]pyridine · in 1 record
- QX2 · 5,6,7-tris(bromanyl)-1~{H}-imidazo[4,5-b]pyridine · in 1 record
- QXW · 5,6-dibromo-1H-triazolo[4,5-b]pyridine · in 1 record
- RXE · ~{N}'-[2-(3,4-dichlorophenyl)ethyl]-~{N}-[4-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]butyl]butanediamide · in 1 record
- TBS · 4,5,6,7-tetrabromobenzotriazole · in 1 record
Experiment against prediction
- 3OFM chain A against the predicted model P19784: TM-score 1.00, RMSD 0.39 Å
- 3OFM chain A against the predicted model P19784: TM-score 1.00, RMSD 0.39 Å
- 3U87 chain A against the predicted model P68400: TM-score 1.00, RMSD 0.44 Å
- 3U87 chain A against the predicted model P68400: TM-score 1.00, RMSD 0.44 Å
- 6L20 chain D against the predicted model P19784: TM-score 0.99, RMSD 0.47 Å
- 6QY8 chain D against the predicted model P19784: TM-score 0.99, RMSD 0.49 Å
- 6QY8 chain D against the predicted model P19784: TM-score 0.99, RMSD 0.49 Å
- 6TGU chain A against the predicted model P19784: TM-score 0.99, RMSD 0.50 Å
- 6L20 chain A against the predicted model P19784: TM-score 0.99, RMSD 0.49 Å
- 8QCD chain A against the predicted model P19784: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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