MolNFT v2 · #129049 · protein
Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand CGA159527
5NWZ: “Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand CGA159527”. X-ray diffraction at 2.37, 1 ligand (9CT). MolNFT v2 #129049 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5NWZ
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.37
- Source
- Homo sapiens
- UniProt
- P22455
- Ligands
- 9CT
Structure
x-ray diffraction · resolution 2.37 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 271 | — | P22455 |
| B | — | protein | 268 | — | P22455 |
Ligands and binding sites
- 9CT · ~{N}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{H}-pyrazol-5-yl]-2-(propanoylamino)benzamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5NWZ · Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible… · the same entry in another collection · chain A against A, TM-score 1.00
- P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22455
- Elsewhere: RCSB PDB 5NWZ · PDBe 5NWZ · UniProt P22455
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