MolNFT v2 · #122108 · protein

Structure of complement C5 in complex with eculizumab

5I5K: “Structure of complement C5 in complex with eculizumab”. X-ray diffraction at 4.2, 2 ligands (NAG, BMA). MolNFT v2 #122108 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5I5K
Type: protein
Length: 4,134 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 4.2
Source: Homo sapiens
UniProt: P01031
Ligands: NAG, BMA

Structure

x-ray diffraction · resolution 4.2 · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	—	protein	1634	—	P01031
H, X	—	protein	221	—	—
L, Y	—	protein	213	—	—
A	—	protein	1632	—	P01031

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains B, A
BMA · beta-D-mannopyranose · sugar · 2 copies

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5I5K · Structure of complement C5 in complex with eculizumab · the same entry in another collection · chain Y against Y, TM-score 1.00
P01031 · AlphaFold monomer V2.0 prediction for complement C5 (P01031) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01031
Elsewhere: RCSB PDB 5I5K · PDBe 5I5K · UniProt P01031

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