GL1X · GenesisL1 explorer

MolNFT v2 · #121751 · protein

5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine

5HVB: “5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine”. X-ray diffraction at 1.6, 2 ligands (65O, NDP). MolNFT v2 #121751 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
5HVB
Type
protein
Length
186 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
1.6
Source
Homo sapiens
UniProt
P00374
Ligands
65O, NDP

Structure

x-ray diffraction · resolution 1.6 · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein186—P00374

Ligands and binding sites

  • 65O · 5-methyl-6-(naphthalen-1-ylsulfanyl)thieno[2,3-d]pyrimidine-2,4-diamine · ligand · chains A
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 5HVB · 5-methyl-6-(1-NAPHTHYLTHIO)THIENO[2,3-D]PYRIMIDINE 2,4-diamine · the same entry in another collection · chain A against A, TM-score 1.00
  • P00374 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P00374) · a predicted model of the same protein · chain A against A, TM-score 0.98

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