MolNFT v2 · #116950 · protein
Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe
5DKD: “Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe”. X-ray diffraction at 2, 2 ligands (5BW, ZN). MolNFT v2 #116950 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5DKD
- Type
- protein
- Length
- 220 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens
- UniProt
- P51532
- Ligands
- 5BW, ZN
Structure
x-ray diffraction · resolution 2 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 110 | — | P51532 |
Ligands and binding sites
- 5BW · (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5DKD · Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with pfi-3… · the same entry in another collection · chain A against A, TM-score 1.00
- P51532 · AlphaFold monomer V2.0 prediction for transcription activator BRG1 (P51532) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51532
- Elsewhere: RCSB PDB 5DKD · PDBe 5DKD · UniProt P51532
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